1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

Bioorg Med Chem Lett. 1999 Jun 21;9(12):1721-6. doi: 10.1016/s0960-894x(99)00266-8.

Abstract

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CHO Cells
  • Cell Death
  • Cricetinae
  • Excitatory Amino Acid Agonists / chemical synthesis
  • Excitatory Amino Acid Agonists / pharmacology
  • Mice
  • N-Methylaspartate / toxicity
  • Neurons / drug effects
  • Neuroprotective Agents / chemical synthesis
  • Neuroprotective Agents / pharmacology*
  • Proline / analogs & derivatives*
  • Proline / chemical synthesis
  • Proline / pharmacology
  • Receptors, Metabotropic Glutamate / agonists*

Substances

  • 1,4-diaminopyrrolidine-2,4-dicarboxylic acid
  • Excitatory Amino Acid Agonists
  • Neuroprotective Agents
  • Receptors, Metabotropic Glutamate
  • N-Methylaspartate
  • Proline