Abstract
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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CHO Cells
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Cell Death
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Cricetinae
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Excitatory Amino Acid Agonists / chemical synthesis
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Excitatory Amino Acid Agonists / pharmacology
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Mice
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N-Methylaspartate / toxicity
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Neurons / drug effects
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / pharmacology*
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Proline / analogs & derivatives*
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Proline / chemical synthesis
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Proline / pharmacology
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Receptors, Metabotropic Glutamate / agonists*
Substances
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1,4-diaminopyrrolidine-2,4-dicarboxylic acid
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Excitatory Amino Acid Agonists
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Neuroprotective Agents
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Receptors, Metabotropic Glutamate
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N-Methylaspartate
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Proline